IFNG [IFNG/3996R]

Interferon-gamma (IFNG) is a cytokine secreted predominantly by activated lymphocytes such as CD4 T helper type 1 (Th1) cells and CD8 cytotoxic T cells, natural killer cells, B cells, and antigen-presenting cells. IFNG expression is induced by mitogens and cytokines (1). The downstream target genes of IFNG signaling pathway regulate several biological functions, including cell cycle, apoptosis, and inflammation (2). In adaptive immunity, IFNG directly regulates the differentiation, activation, and homeostasis of Th1 cells; inhibits Th2 cell development; promotes regulatory T cell development and natural killer cell activity; and induces class I MHC expression (3).

Specifications

1. Castro F, Cardoso AP, Gonçalves RM, et al. Interferon-gamma at the crossroads of tumor immune surveillance or evasion. Front Immunol. 2018; 9:847.
2. Zaidi MR. The interferon-gamma paradox in cancer. J Interferon Cytokine Res. 2019;39(1):30-38.
3. Benci JL, Johnson LR, Choa R, et al. Opposing functions of interferon coordinate adaptive and innate immune responses to cancer immune checkpoint blockade. Cell. 2019;178(4):933-948.
4. Center for Disease Control Manual. Guide: Safety Management, NO. CDC- 22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
5. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory Workers from Occupationally Acquired Infections; Approved Guideline-Fourth Edition CLSI document M29-A4 Wayne, PA 2014.