SALL4

SALL4 is required for the maintenance of embryonic stem cell pluripotency by modulating Oct4. Studies support SALL4 as a sensitive and specific marker for seminomas and ovarian primitive germ-cell tumors. Studies have demonstrated that over 90% of tumor cells in intratubular germ-cell neoplasias and embryonal carcinomas show strong SALL4 staining. In addition, 100% of 31 yolk sac tumors (5 pediatric and 26 postpubertal) showed strong positive SALL4 staining of tumor cells, but were negative for Oct4. SALL4 antibody is a promising pan germ-cell marker, with studies showing that it is superior to PLAP and Oct4 antibodies.

Specifications

1. Cao D, et al. SALL4 is a novel sensitive and specific marker for metastatic germ cell tumors, with particular utility in detection of metastatic yolk sac tumors. Cancer. 2009 Jun 15; 115 (12): 2640-51.
2. Cao D, et al. SALL4 is a novel sensitive and specific marker of ovarian primitive germ cell tumors and is particularly useful in distinguishing yolk sac tumor from clear cell carcinoma. Am J Surg Pathol. 2009 Jun; 33(6): 894-904.
3. Cui W, et al. Differential expression of the novel oncogene, SALL4, in lymphoma, plasma cell myeloma, and acute lymphoblastic leukemia. Mod Pathol. 2006 Dec; 19 (12): 1585-92. Epub 2006 Sep 22.
4. Ma Y, et al. SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice. Blood. 2006 Oct 15; 108 (8): 2726-35. Epub 2006 Jun 8.
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6. National Committee for Clinical Laboratory Standards (NCCLS). Protection of laboratory workers from infectious diseases transmitted by blood and tissue; proposed guideline. Villanova, PA 1991;7(9). Order code M29-P.