Description
The ZytoLight ® SPEC FGFR1 Dual Color Break Apart Probe is designed to detect rearrangements involving the chromosomal region 8p11.23-p11.22 harboring the FGFR1 gene. Translocations affecting FGFR1 are hallmarks of the 8p11 myeloproliferative syndrome also known as stem cell leukemia/lymphoma syndrome, an aggressive stem cell myeloproliferative neoplasm that is associated with eosinophilia, poor prognosis, T-cell lymphoma, and frequent progression to acute myeloid leukemia.
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